Preston moved to within four points of the Championship play-offs as they inflicted a first defeat on Hull City head coach Shota Arveladze.
Cameron Archer hit the post for Preston with a turn and shot in an entertaining and even first half which somehow ended goalless.
Aston Villa loanee Archer then showed fine skill to bring down the ball on his chest and slotted past Tigers goalkeeper Matt Ingram.
Hull were denied an equaliser when Tom Eaves' header was ruled out for offside as new owner Acun Ilicali tasted defeat for the first time since last month's takeover.