Hull City, Sunderland and Peterborough United all reached the quarter-finals of the Papa John's Trophy on Tuesday.
Hull came from 2-0 down at home to beat Fleetwood 3-2, with Lewie Coyle netting a long-range winner in the 94th minute.
A late penalty from Aiden McGeady sealed a 2-0 win for the Black Cats over Port Vale, while Posh thrashed last season's finalists Portsmouth 5-1.
AFC Wimbledon, Lincoln City, MK Dons and Oxford United also booked their places in the last eight.
League One leaders Lincoln beat Accrington 4-0 and a first senior goal from Jack Rudoni gave Wimbledon victory at Bristol Rovers.