In the first Saturday Night Football game of the season, the red hot 9-4 New England Patriots travel to Lucas Oil Stadium to take on the 7-6 Indianapolis Colts.
Both teams are coming off their bye week and have huge implications on tonight’s game.
The Patriots can clinch a playoff berth with a win and some help from other teams on Sunday and Monday.
Meanwhile, a Colts loss would put the Tennessee Titans in position to clinch the AFC South with a win tomorrow against the Pittsburgh Steelers.