Hello, good evening, and welcome to Week 3 and Thursday Night Football. Tonight, we have a coast-to-coast matchup between the New York Giants (+10.5)
(because we have to have an NFC East team in every single prime time game) and the San Francisco 49ers (-10.5).
The Niners are 10.5 point favorites tonight against the Giants, which is a significant gap between the two teams. Speaking for myself, when the point spread gets higher, I like to pick the underdogs more. Not because I believe in their ability to win but because the likelihood of any NFL team beating another NFL team by double digits is usually pretty low.