The Texans placed five-time Pro Bowl wide receiver Demaryius Thomas on injured reserve with a ruptured Achilles tendon.
Thomas got hurt against the Philadelphia Eagles. He will undergo surgery to repair the damage.
Meanwhile, the Texans also placed cornerback Kayvon Webster on injured reserve for the second time.
Webster was activated from injured reserve-designated to return and injured his thigh against the Eagles.
A special-teams ace, inside linebacker Brian Peters was also placed on injured reserve.
The Texans promoted wide receiver Steven Mitchell from the practice squad to the active roster.
They signed linebacker Chris Landrum to the practice squad and cut linebacker Kennan Gilchrist.