Texans starting offensive guard Zach Fulton hasn't practiced all week due to ankle injury and is regarded as unlikely to play Sunday against the Jacksonville Jaguars.
Signed to a four-year, $28 million contract in March, Fulton is one of the Texans' better blockers.
Fulton would be replaced in the starting lineup by Greg Mancz, who started every game at center two seasons ago and was recently signed to a two-year, $6 million contract.
“He’s done it for us before," Texans coach Bill O'Brien said. "Center, guard, he’s really done everything we’ve asked him to do. Played a lot of football for us.