The Texans made it official, ruling out tight ends Ryan Griffin and Stephen Anderson and wide receiver Bruce Ellington and middle linebacker Brian Cushing due to concussions.
The Texans previously placed tight end C.J. Fiedorowicz on injured reserve with a concussion.
The Texans also ruled out offensive guard Jeff Allen due to an ankle injury as well as running back Alfred Blue (high-ankle sprain) and wide receiver Will Fuller (broken collarbone).
Rookie quarterback Deshaun Watson (ankle) participated fully for the second day in a row and is poised to make his starting debut against the Cincinnati Bengals on Thursday night.