A 21-yard touchdown reception by DeAndre Hopkins put Houston on top in the second quarter and the Texans (3-5) didn’t trail after that. Nate Washington’s 42-yard TD catch extended the lead to 17-6 in the third.
Zach Mettenberger threw for 171 yards with an interception in his second straight start in place of rookie Marcus Mariota, who is out with a knee injury. Mettenberger was hurried and harassed all day to remain winless in eight career starts, with three against the Texans.
The Titans (1-6) had three turnovers in their sixth straight loss since a win over Tampa Bay in the opener.