Texans outside linebacker John Simon's chest injury is considered serious enough that he won't play against the San Diego Chargers on Sunday.
Simon got hurt against the Oakland Raiders, leaving the game and not returning.
Simon was replaced at outside linebacker by backup inside linebacker Akeem Dent. Dent has two tackles this season.
Simon ranks second on the Texans' defense with 50 tackles and 3 1/2 sacks.
"Our team has really taken the mantra of 'next man up,' and that's what it's going to have to be with John because he'll be out for a bit," Texans coach Bill O'Brien said.