The veteran safety and kick returner announced his retirement during a Tuesday afternoon appearance on Texans Radio.
"I decided I'm going to hang the cleats up," Manning said. "I'm officially retiring."
Manning entered the NFL as a second round pick in 2006, spending his first five years as a Chicago Bear. He signed a free agent deal with the Texans in 2011, and along with free agent cornerback Johnathan Joseph, instantly stabilized what had become a shaky secondary.
As a Texan, Manning started 40 of the 51 games he played. He picked off four passes with Houston, returning one for a touchdown in 2012.