It's unfair to say that former Houston Texans general manager Charley Casserly single-handedly piloted the Good Ship Texan into the depths of Hades during his reign of terror at Reliant NRG Park, but it's entirely fair to reason that he had a sizable hand in the Texans' floundering from 2002 to 2006. A large part of that failure was due to--you guessed it--the NFL Draft.
Here's a link to the Houston Texans' entire draft history. Here are the drafts Charley Casserly managed (despite Casserly still being GM for the 2006 NFL Draft, we're not including that one in this exercise, as it was widely understood that Casserly was not the one in charge of the room that weekend; he was on his way out, as witnessed by his resignation a few weeks afterward).