The Dynamo had their eyes set on victory to open the 2018 season. Following claims that their 2017 season was a fluke, Houston took the field against Atlanta to prove naysayers wrong. A 4-0 thrashing was the result, as the Dynamo continued their home field advantage run. Goals came from Mauro Manotas, Andrew Wenger, Darwin Ceren, and Philippe Senderos, with Alberth Elis, Senderos, and Head Coach Wilmer Cabrera all making the MLS Team of the Week.
Newcomer Kei Kamara and young star Alphonso Davies showed what they were capable of for Vancouver in a 2-1 victory over Montreal.