Houston guard Jamal Shead is questionable to return to Friday's Sweet 16 contest against Duke after suffering a right ankle injury, the team announced at halftime.
Shead slipped on a layup and fell at 6:38 of the first half.
He appeared to be in pain and had to be helped to the locker room.
CBS SportsJamal Shead is heading into the locker room <a href="https://t.co/f9n70VsDad">pic.twitter.com/f9n70VsDad</a>
Shead had two points on 1-for-5 shooting, with three assists and one rebound, prior to exiting the game.
His absence represents a significant loss for Houston's defense.