There are essentially two objectives for the Astros as they finish out September: Stay healthy (as much as a baseball player reasonably can be this late in the season), and clinch the number one seed in the AL. The latter is increasingly likely with an eight-game lead over the Yankees with only 12 games remaining on the schedule. Unfortunately, the former is still up in the air as long as regular season games remain. Might I recommend they bubble wrap a couple of players as a precautionary measure?
Barring injury, however, the roster does appear fairly set heading into the postseason, at least among its core players.