Colon (1-4) fell behind 5-0 before recording an out, but he came back to send down 13 of the next 14 batters faced. Reddick hit a home run -- the 100th of his career -- to push the Houston lead to 6-0 in the fifth.
Astros starter Charlie Morton (4-2) cruised into the sixth before his command betrayed him. Matt Kemp and Nick Markakis had RBI singles in the sixth, and Morton was pulled after he walked Dansby Swanson with the bases loaded to get the Braves to within three runs, 6-3.