The Red Sox jumped out to a 1-0 advantage thanks to David Ortiz's RBI single in the opening inning, giving Buchholz an early edge. Other than an RBI groundout in the second, Buchholz was cruising through the Houston order prior to the bumpy fifth inning. He took the loss, and the Red Sox are now winless in his first four 2016 starts.
Brock Holt and Josh Rutledge plated runs for Boston in the later innings, but Rasmus, Luis Valbuena and Jose Altuve countered with RBI doubles in the eighth to pad the lead.