White Sox starter Carson Fulmer left the game in the first inning with a blister, and Chris Volstad came out of the bullpen and threw 4 1/3 innings, allowing one run and three hits. Astros starter Dallas Keuchel battled his control early, issuing a bases-loaded walk to Rymer Liriano in the second and walking Yoan Moncada to start the third and allowing him to score.
The only run the Astros managed came in the third when catcher Brian McCann hit an upper-deck homer to right field to cut Chicago's lead to 2-1.