Astros rookie starter Joe Musgrove (2-2) bounced back from a pair of subpar starts by holding the A's scoreless for 5 1/3 innings despite battling control issues. A's starter Sean Manaea (5-9) left the game in the fourth after only 61 pitches with a muscle strain in his upper back.
The Astros took a 2-0 lead in the second on consecutive two-out, bases-loaded walks by Jake Marisnick and George Springer which followed a pair of fielding errors by Oakland third baseman Ryon Healy. Altuve's homer in the sixth made it 3-0, and the Astros scored three times in the seventh on Bregman's two-run single and an RBI single by Carlos Correa.