1:00 PM ET Games
San Francisco @ Buffalo
Vegas Projected Score: Bills 26.5, 49ers 17.5
Fresh off their third consecutive upset victory, the Bills return home as nine-point favorites against a 49ers team that has lost four straight. This is a pristine matchup for red-hot LeSean McCoy against a Navorro Bowman-less San Francisco defense that has allowed the second most run plays in the NFL (167) and four straight 100-yard rushers (Fozzy Whittaker, 16-100; Christine Michael, 20-106-2; Ezekiel Elliott, 23-138-1; David Johnson, 27-157-2). San Francisco has yielded a combined 123-612-5 (4.