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Packers LB Nick Perry out vs Seattle with hand injury (The Associated Press)

GREEN BAY, Wis. (AP) -- The Packers' banged-up defense has taken another hit with linebacker Nick Perry ruled out for Sunday's game against the Seattle Seahawks with what coach Mike McCarthy called a ''significant hand injury.''

Perry leads the team with eight sacks. He got hurt in the first half of last week's win over Houston before returning after halftime playing with a heavily-wrapped left hand.

McCarthy said Wednesday that he didn't know how long Perry would be sidelined, but that the pass rusher would be re-evaluated on Monday.

The loss of Perry is the latest blow to a defense that has had injuries mount at cornerback and now linebacker.