On a December evening in 2010, the Green Bay Packers played the New England Patriots in Foxboro. In a season that would eventually see the Packers go on to win the Super Bowl, the Packers were 14.5 underdogs in a game that was a presumptive cakewalk for Bill Belichick, Tom Brady and company.
The Patriots entered the game at 11-2 and were en route to a 14-2 season that would see Brady selected as the first unanimous MVP in the history of the league.
(They would eventually be bounced in the divisional round in one of the greatest postseason upsets of the last several decades by the New York Jets.