Fantasy football leagues that play right through the end of the NFL schedule can be very tricky. There are NFL teams that have nothing to play for, so it's hard to predict how they will use their players.
For example, the Giants, Steelers, Texans and Cowboys all have their spots in the postseason set in stone. There is a very good chance they will rest at least some of their starters for Week 17 to keep them healthy for the playoffs. The Patriots are playing for home field advantage but could easily lock that up early and sit their starters for the second half of their matchup with Miami.