The San Francisco 49ers suffered their biggest loss of the season in Week 12 on the road against the Green Bay Packers. The 38-10 setback marked the 49ers' biggest margin of defeat since Week 9 of the 2018 season, a 39-10 loss to the Los Angeles Rams.
San Francisco had a season-low 241 yards of offense against the Packers and committed three turnovers for the third time this season. They were operating without Brock Purdy at quarterback for the first time in two years as Brandon Allen started in his place.