Tyler Shough threw for 293 yards and two touchdowns to lead Louisville to a convincing 37-9 victory over visiting Pitt in their Atlantic Coast Conference matchup on Saturday. Isaac Brown rushed for 93 yards and two scores on 13 carries for the Cardinals (7-4, 5-3 ACC), who racked up 505 yards. Louisville dominated on both sides of the ball and led 34-0 just 62 seconds into the third quarter after Chris Bell's 68-yard catch-and-run touchdown on a flat pass from Shough. Bell finished with 101 yards receiving on two catches. The Panthers (7-4, 3-4) entered Saturday averaging nearly 429 yards a game, but the Cardinals allowed just 265 and forced three turnovers as Pittsburgh lost its fourth straight contest.