Isaac Brown rushed for 151 yards, including a game-sealing 45-yard touchdown burst with 5:50 to play, as Louisville went to Clemson and stunned the No. 11 Tigers 33-21 in the Atlantic Coast Conference matchup on Saturday night. Louisville (6-3, 4-2 ACC) scored on seven of its 11 possessions while Clemson (6-2, 5-1) mostly struggled to sustain drives. Louisville posted touchdowns on its last two possessions of the first half, then got field goals of 42, 40 and 49 yards by Brock Travelstead in the third quarter. Clemson pulled within 26-14 on Phil Mafah's 3-yard run with six minutes left in the game, but Louisville recovered the onside kick and set up Brown's late heroics.