Tech hung with Clemson for three quarters, only facing a one-score deficit with two minutes left in the third quarter, but the Tigers proved their top-four ranking in the final frame, pulling away for a 41–10 win. Clemson was favored by 24 points entering the matchup, a game in Mercedes-Benz Stadium that had over 47,000 fans in attendance which featured a sea of orange. The game was part of the Chick-fil-A kickoff series and was the final game of the opening week of the 2022 season.
Clemson won the toss and deferred, kicking the ball to Tech for a touchback.