Greene played quarterback at the University of Georgia in college. He began his career as a redshirt freshman in 2001, being named the starter before the season. His most notable freshman game occurred at #5 Tennessee on October 6, known as the “Hobnail Boot” game. This phrase was coined by Georgia’s famous play-by-play announcer Larry Munson. After Tennessee took the lead in the fourth quarter on a successful screen pass with :44 left, Greene led the Bulldogs back down the field with an inspiring series of quick passes. The winning touchdown pass went to fullback Verron Haynes in a now famous play known as “P-44 Haynes” or the “Hobnail Boot” play with just five seconds remaining on the clock.