Over the course of decades and years upon years of a college football conference series between two teams, even in one-sided matchups, normally both teams can muster at least one win. Even Vanderbilt beat Alabama, Kansas beat Oklahoma, and Kentucky beat Florida at least once.
But in the ACC, never has Duke vanquished Florida State on the gridiron. FSU is truly unconquered with a 20-0 record against the Blue Devils. Other than the latest meeting in 2017, the Seminoles won the first 19 games by two touchdowns or more every single time.