Missouri scored in the first five innings en route to a 22-1 win over FIU on Saturday night at the FIU ballpark.
The Tigers (2-0) got out to an 11-0 lead before the Panthers (0-2) scored in the middle game of a three-game series.
Missouri scored four runs off FIU freshman starter Logan Allen (0-1) in the first inning to build a 4-0 lead.
Kameron Misner led the Tigers offense going 3 for 5 with two home runs and five RBI.
The Panthers scored their run in the bottom of the fourth inning on back-to-back doubles from Juan Teixeira and Javier Valdes.