Notre Dame won its season opener under the watch of Touchdown Jesus but now the Fighting Irish hit the road, where they're just 3-6 both straight up and against the spread over the last two seasons. Notre Dame hopes to turn those trends around when it takes on Virginia Saturday in Charlotttesville.
Point spread: Fighting Irish opened as 11.5-point favorites, according to sportsbooks monitored by Odds Shark. (Line updates and matchup report)
College football pick, via Odds Shark computer: 26.8-21.6 Fighting Irish
Why the Notre Dame Fighting Irish can cover the spread
The Irish opened this season with a 38-3 victory over Texas, easily covering as nine-point favorites.