Since playing in the national championship game four seasons ago, Notre Dame is just 18-15 straight up against major-conference competition. Some might argue otherwise, but Syracuse qualifies as a major-conference team. How will the Irish fare when they roll with the Orange on Saturday afternoon on a neutral field at MetLife Stadium in New Jersey?
Point spread: The Fighting Irish opened as 12-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 37.6-10.7, Fighting Irish (college football picks on every game)
Why the Notre Dame Fighting Irish can cover the spread
Notre Dame is looking to regroup following two straight home losses.