The Duke Blue Devils aren't exactly known as road warriors, but they are 13-4 straight up and 12-5 against the spread over their last 17 games away from home. Duke faces a stiff road test this week as it heads up to South Bend to take on the Fighting Irish of Notre Dame on Saturday afternoon.
Point spread: The Fighting Irish opened as 20-point favorites, according to sportsbooks monitored by Odds Shark (line updates and matchup report).
College football pick, via Odds Shark computer: 38.0-25.1 Fighting Irish (college football picks on every game)
Why the Duke Blue Devils can cover the spread
The Blue Devils opened this season well enough, beating North Carolina Central 49-6, but they have lost two tough ones in a row since then.