Week 13 represents the end of most fantasy football regular seasons, which makes this a crucial week across the landscape. This specific Week 13 is unique for an unfortunate reason. Two of the league’s best running backs, Melvin Gordon and Leonard Fournette, will be out due to injury and suspension, respectively. Two more who are among the top-18 backs in points per game, Marlon Mack and Kerryon Johnson, could also sit this week because of injury. That’s four locked-in starters, including the No. 3 overall back in Gordon, who will or could miss Week 13, and that’s a nightmare for their fantasy owners.