Injuries have been an early storyline of the 2021 NFL season. We have already seen fantasy staples like Christian McCaffrey, Dalvin Cook and Jarvis Landry ruled out, and the Week 5 injury list included the likes of Russell Wilson, Clyde Edwards-Helaire and Saquon Barkley.
With several injuries to consider, and the Atlanta Falcons, New Orleans Saints, San Francisco 49ers and New York Jets on bye, many fantasy managers will be forced to play fringe starters at key positions in Week 6.
Here, we'll examine several second-tier players—those rostered in between 30 and 80 percent of Yahoo and/or ESPN leagues, according to FantasyPros—who have enticing or concerning matchups or situations for the week.