Running back Jonathan Taylor was placed on the reserve/COVID-19 list Saturday, which will cause the to go further down the depth chart to fill out the backfield for Sunday's game against the Tennessee Titans.
Week 1 starter Marlon Mack was already ruled out for the season with a torn Achilles, paving the way for Taylor to become the go-to option.
His absence could force Nyheim Hines into a bigger role after showcasing his ability both as a runner and receiver this season.
The third-year player entered Week 12 with 179 rushing yards and 296 receiving yards, totaling six touchdowns in 10 games.