I'm a big fan of the matchup defense, meaning you choose your defense based more on who the defense is playing than the defense itself. The byes shouldn't hurt your options too badly this week. I list the top 10 only because I base my rankings on a standard, 10-team league.
Byes: New York Giants & San Francisco 49ers
Last Update: Oct. 25
Other Rankings: QB, RB, WR, TE, DEF
| Rank & Team | Opponent | Notes |
| 1. Dolphins | @JAC | A great matchup for the Dolphins. |
| 2. Lions | @ATL | The Lions defense has been really good this season. |
| 3. Texans | @TEN | The Titans are playing Mettenberger, and opposing defenses love to feast on rookies. |
| 4. Bills | @NYJ | Solid matchup here for the Bills. |
| 5. Chiefs | STL | Good matchup for the Chiefs. |
| 6. Seahawks | @CAR | Seahawks defense hasn't been great, but I think they'll bounce back soon. |
| 7. Cowboys | WAS | Honestly didn't think I would be recommending the Cowboys as a viable starting defense this season. |
| 8. Browns | OAK | The Browns are an acceptable matchup play against the Raiders. |
| 9. Ravens | @CIN | If you're desperate, you could do worse than this. |
| 10. Patriots | CHI | The Patriots are a decent play this week. |