I'm a big fan of the matchup defense, meaning you choose your defense based more on who the defense is playing than the defense itself. However, with the Dolphins and Raiders on bye, the matchup options aren't as strong this week. I list the top 10 only because I base my rankings on a standard, 10-team league.
Byes: Miami Dolphins & Oakland Raiders
Last Update: Oct. 2
Other Rankings: QB, RB, WR, TE, DEF
| Rank & Team | Opponent | Notes |
| 1. Seahawks | @WAS | The Seahawks defense is going up against Kirk Cousins. What more do you need? |
| 2. Steelers | @JAC | The Jaguars are terrible. |
| 3. Bengals | @NE | The Patriots offense is terrible and the Bengals defense is good. |
| 4. Lions | BUF | The Bills have a new QB and the Lions defense has played well for much of the season. |
| 5. Eagles | STL | I'm not a fan of the Rams' offense and the Eagles have been a good fantasy defense. |
| 6. 49ers | KC | The 49ers defense has done well so far, but this could be a tricky matchup. |
| 7. Broncos | ARI | Not a great matchup, but you could do worse. |
| 8. Browns | @TEN | The Titans offense hasn't been good and the Browns have a solid defense. |
| 9. Packers | @MIN | You could do worse this week. |
| 10. Patriots | CIN | Maybe bad Andy Dalton shows up. |