The trio replace Kurt Zouma, Ademola Lookman and Cenk Tosun from the side that drew 1-1 with Newcastle United last Wednesday as Silva reverts to the XI he selected for three straight outings prior to the visit of the Magpies.
Walcott’s inclusion means he racks up a 300th Premier League appearance, while there is also a top-flight milestone for Keane, who reaches three figures in the competition.
Keane will take his place in defence alongside Yerry Mina, Lucas Digne and stand-in skipper Seamus Coleman, a back five completed by goalkeeper Jordan Pickford and once again protected by the pairing of Andre Gomes and Idrissa Gana Gueye in midfield.