Timo Werner is the latest Tottenham player to be ruled out by a hamstring injury.
Ange Postecoglou has ruled the Germany forward, on loan from Leipzig, out for up to four weeks after scans revealed the damage.
Werner's form has been poor, but his absence deprives the Spurs boss of options and flexibility from the bench, just when he thought his injury crisis was starting to ease.
Richarlison and Mikey Moore have returned to the first team in the last week and defender Ben Davies is expected to be back for the game at Everton on Sunday.