Everton striker Wayne Rooney returns to Old Trafford for the first time since his summer departure as the struggling Toffees look to upset the odds against Manchester United.
Jose Mourinho's side will take to the field for the first time since losing Paul Pogba to a hamstring injury but the Portuguese boss was adament this week that he had the squad to cope.
Marouane Fellaini will be the man to step into midfield while left-back Luke Shaw is also available but has failed to make the match-day squad.
Dominic Calvert-Lewin could partner Rooney in the Everton attack as Ronald Koeman looks for a response from his team after two abject defeats - against Tottenham and Atalanta.