Everton will look to kick-start their FA Cup journey with a comfortable win over Championship strugglers Rotherham in the third round at lunchtime.
Carlo Ancelotti is expected to ring the changes for the clash at Goodison Park, which gets underway at 12pm, and will want to avoid a potential giant killing as the biggest teams in the country finally enter the competition.
Elsewhere, Reading will travel to Luton, Norwich host Coventry and Nottingham Forest take on Cardiff.
Non-league Boreham Wood are aiming to spring a shock against Millwall, with minnows Chorley also hoping to make their dreams come true against a coronavirus-ridden Derby.