Everton goalkeeper Jordan Pickford had to be substituted just before half-time during his side's 2-1 home defeat by Burnley.
The 27-year-old attempted to play on but was unable to continue and was withdrawn in the 43rd minute.
Pickford injured himself as he stretched to try and keep out an effort from Johann Gudmundsson, which hit the post.
The 21-year-old Joao Virginia replaced Pickford to make his Premier League debut.
Virginia, a Portuguese youth international, joined Everton from Arsenal in 2018 and previously had a loan spell at Reading.