Martin O'Neill has confirmed that Republic of Ireland skipper Seamus Coleman suffered a broken leg in a horror challenge by Wales defender Neil Taylor.
The Everton full-back was carried from the field on a stretcher after Taylor had been shown a straight red card for his 69th-minute tackle during Friday night's 0-0 World Cup qualifier draw in Dublin.
Republic boss O'Neill said: "Seamus has gone to hospital. It's been confirmed by our doctor that he has broken his leg. It's a real blow to him.
"He's having the season of a lifetime at club level and he's a big player for us, a great captain and a a great character, so it's a big, big loss, a big loss to Everton, a big loss to us.