Beni Baningime will make his full Premier League debut for Everton, with Oumar Niasse also in the Blues' starting XI to take on Watford.
Baningime has been given the nod after starting recent matches against Chelsea in the Carabao Cup and Lyon in the Europa League.
The 19-year-old is joined in Everton's midfield by fellow Academy graduate Tom Davies, and Idrissa Gana Gueye.
Niasse will lead a Toffees' attack which also includes Wayne Rooney and Gylfi Sigurdsson, while Michael Keane returns to the backline after recovering from a recent infection.