Next up for Duke is a rematch with Pitt and after a 35 point win up there by Duke, it’s hard to make a case for Pitt to win in Cameron. Hard but not impossible.
The first element of a Pitt upset - of almost any upset really - is the cooperation of the favored team. If Duke comes in to this one expecting to win and expecting Pitt to roll over they’ll be in trouble.
The second thing that could theoretically work in Pitt’s favor is Duke’s youth. The team is improving fast but the four freshmen are still freshmen.