The Tigers entered the sixth trailing, 3-2, but broke out for three runs with the help of three wild pitches, including a run-scoring wild pitch from Twins starter Kyle Gibson. Reliever Michael Tonkin gave up a two-run single to Cameron Maybin with two outs to give the Tigers a lead they wouldn't relinquish.
Detroit put away the game with three runs against Tonkin in the seventh, with Erick Aybar connecting on a solo shot and Victor Martinez launching a two-run blast.
The offense backed right-hander Anibal Sanchez, who went seven innings, allowing three runs on six hits.