The Tigers won the opener, 5-4, in exciting fashion as Javier Baez's fly to right scored the winner in the bottom of the ninth.
After tying the game in the eighth on a two-RBI single from Miguel Cabrera, Andrew Vaughn homered in the ninth to give the White Sox a 4-3 lead. But Eric Haase answered with a home run of his own with one out in the bottom of the ninth to tie the game, 4-4.
After Robbie Grossman struck out, Austin Meadows tripled to right center before the Baez hit.
The hit was first called an out as right fielder AJ Pollock appeared to make a circus catch at the wall to end the inning with the game tied at 4.