Tigers starter Justin Verlander needs seven strikeouts to reach 2,000 for his career. He will face Twins batters Joe Mauer (.274), Eduardo Nunez (.333) and Miguel Sano (.239) in the top of the first.
The only other Tiger in franchise history to reach 2,000 strikeouts was Mickey Lolich (1963-75), who posted 2,679.
How to watch: Detroit Tigers vs. Minnesota Twins
The Tigers take aim at their fourth straight win and a sweep of the Twins in a 1:10 p.m. game Wednesday at Comerica Park.
Justin Verlander, coming off two consecutive excellent outings, starts for the Tigers.