The Tigers, who got a leadoff walk from James McCann against right-hander Michael Ynoa to lead off the top of the seventh inning, were unable to move him up.
JaCoby Jones grounded into a 5-4-3 double play before Jose Iglesias grounded out to third baseman Todd Frazier to end the inning.
Going to the bottom of the seventh, the Tigers are still behind, 10-1.
White Sox add run in 6th
Anibal Sanchez allowed another run in the bottom of the sixth inning.
After Melky Cabrera doubled to the wall in right on a ball misplayed by Tyler Collins, and took third on a ball in the dirt that got past catcher James McCann, he scored on an RBI single from Jose Abreu, making it 10-1.