Tigers right-handed starter Anibal Sanchez recorded his sixth strikeout of the night to end the top of the fourth inning.
The White Sox lead 1-0 at Comerica Park.
Avisaíl García continued his success against the Tigers with a leadoff single, but White Sox left fielder Nicky Delmonico grounded into a 4-6-3 double play. From there, White Sox designated hitter Matt Davidson drew a walk, but Sanchez struck out shortstop Tim Anderson to end the frame.
Garcia is 26-for-62 (.419) against the Tigers this year. On Thursday, Garcia became the second player in White Sox franchise history to notch five hits and seven RBIs in a game.